ESPCI web site
Le séminaire hebdomadaire du laboratoire PMMH a lieu tous les vendredis à 11h, au premier étage Barre Cassan, campus Jussieu (plan).
Stéphane Perrard
Etienne Reyssat
Virgile Thiévenaz
PMMH
BARRE CASSAN
BAT A 1ER ETAGE CASE 18
7 QUAI SAINT BERNARD
75005 PARIS
France
Tel : (33) 1 40 79 45 22
Séminaire PMMH - Avin Babataheri (Ladhyx)
1D confinement controls cell shape and migration
Pericytes are mural cells of the microvasculature, they wrap around small vessels, support the vessels mechanically and participate in blood flow regulation.
Pericytes are distinguished by two main characteristics ; first their distinct morphology, which has been likened to a “bump on a log”, as they present long processes spanning along the axis of the vessels they adhere to, and a protruding soma that houses the nucleus. The second characteristic is their distribution along the microvascular tree in a cellular chain where each cell occupies its own territory. This spatial distribution is established by cell migration during the embryonic stage and maintained through controlled motility in the adult.
Because of their position in the microvascular tree, pericytes experience extreme lateral and longitudinal confinement, we hypothesize that the confinement impacts their morphology. Although pericyte shape is key for their function during vascular regulation, the manner in which pericyte morphology is associated with migration and function remains unknown.
In this project, we use micropatterns to mimic pericyte adhesion to microvessels, we show that lateral confinement controls cell shape and produces in vivo-like phenotypes. We study pericyte migration on both laterally confining lanes, and longitudinally constraining motifs and propose a model that describes their kinetics as a stochastic motion with dry friction.
In vivo pericytes can bridge nearby capillaries, we show that in vitro pericytes are also capable of crossing gaps of different sizes. The percentage of crossings is correctly predicted by the likelihood of a fluctuating system to overcome an energy barrier. Our joint experimental and theoretical approach demonstrates the effect of in vivo-like geometrical confinement on pericyte morphology and migration.
- Archives des anciens séminaires
- Séminaires récents
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Séminaires récents (10)
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Séminaire PMMH – Vincent Bertin (IUSTI, U. Aix-Marseille)
Vendredi 6 juin de 11h00 à 12h00 - Salle réunion PMMH 1
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Séminaire PMMH – Vincent Bertin (IUSTI, U. Aix-Marseille)
Vendredi 6 juin de 11h00 à 12h00 - Salle réunion PMMH 1
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Séminaire PMMH - José Halloy (LIED, Univ. Paris Cité)
Vendredi 23 mai de 11h00 à 12h00 - Salle réunion PMMH 1
Energy Transition and Earth System Dynamics : Quantifying Long-Term Sustainability Trajectories for Human Societies
This talk explores how current industrial technologies - linear, extractive, and ecologically disruptive - must be replaced by systems designed in harmony with the Earth's living metabolism. Framing the planet as a dynamic, interdependent system rather than a passive resource pool leads to a fundamental rethinking (…) -
Séminaire PMMH - José Halloy (LIED, Univ. Paris Cité)
Vendredi 23 mai de 11h00 à 12h00 - Salle réunion PMMH 1
Energy Transition and Earth System Dynamics : Quantifying Long-Term Sustainability Trajectories for Human Societies
This talk explores how current industrial technologies - linear, extractive, and ecologically disruptive - must be replaced by systems designed in harmony with the Earth's living metabolism. Framing the planet as a dynamic, interdependent system rather than a passive resource pool leads to a fundamental rethinking (…) -
Séminaire PMMH - Julien Scheibert (LTDS, EC Lyon)
Vendredi 16 mai de 11h00 à 12h00 - Salle réunion PMMH 1
Metainterfaces : how to design a rough contact that obeys a specific friction law ?
Many devices, including touchscreens and robotic hands, involve frictional contacts. Optimizing those devices requires fine control of the interface's friction law. We lack systematic methods to create dry contact interfaces whose frictional behaviour satisfies preset specifications. In this seminar, I will present (…) -
Séminaire PMMH - Julien Scheibert (LTDS, EC Lyon)
Vendredi 16 mai de 11h00 à 12h00 - Salle réunion PMMH 1
Metainterfaces : how to design a rough contact that obeys a specific friction law ?
Many devices, including touchscreens and robotic hands, involve frictional contacts. Optimizing those devices requires fine control of the interface's friction law. We lack systematic methods to create dry contact interfaces whose frictional behaviour satisfies preset specifications. In this seminar, I will present (…) -
Séminaire PMMH – Olga Dudko (University of California at San Diego)
Vendredi 18 avril de 11h00 à 12h00 - Salle réunion PMMH 1
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Séminaire PMMH – Olga Dudko (University of California at San Diego)
Vendredi 18 avril de 11h00 à 12h00 - Salle réunion PMMH 1
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Séminaire PMMH - Máté Nagy (Eötvös Loránd University, Budapest)
Vendredi 11 avril de 11h00 à 12h00 - Salle réunion PMMH 1
Physics of animal collective behavior : interactions with one another and their environment
The breathtaking aerial displays and mesmerizing formations of birds, fish shoals and the thunderous gallop of hundreds of horses exemplify captivating group behaviors in nature. Traditional measurement methods fall short in capturing these intricate behaviors arising from simple individual interactions, (…) -
Séminaire PMMH - Máté Nagy (Eötvös Loránd University, Budapest)
Vendredi 11 avril de 11h00 à 12h00 - Salle réunion PMMH 1
Physics of animal collective behavior : interactions with one another and their environment
The breathtaking aerial displays and mesmerizing formations of birds, fish shoals and the thunderous gallop of hundreds of horses exemplify captivating group behaviors in nature. Traditional measurement methods fall short in capturing these intricate behaviors arising from simple individual interactions, (…)
Instructions générales pour les conférenciers
Le public du séminaire est très hétérogène (rien qu’au PMMH nous travaillons sur des thématiques très diverses, mécanique des fluides, des milieux granulaires, des solides, physique statistique, physique du mouillage, micro-fluidique, biophysique,...) l’objectif est donc de ne pas faire un séminaire trop spécialiste : au moins la première moitié du séminaire à un niveau accessible pour celui qui ne connaît rien sur le sujet.
Le séminaire a lieu à 11h. rendez-vous 15 minutes avant pour installer et tester la projection.
Le séminaire dure environ 45 minutes pour laisser un peu de temps pour discuter à la fin.
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