ESPCI web site
Le séminaire hebdomadaire du laboratoire PMMH a lieu tous les vendredis à 11h, au premier étage Barre Cassan, campus Jussieu (plan).
Sylvain Patinet
Stéphane Perrard
Etienne Reyssat
Virgile Thiévenaz
PMMH
BARRE CASSAN
BAT A 1ER ETAGE CASE 18
7 QUAI SAINT BERNARD
75005 PARIS
France
Tel : (33) 1 40 79 45 22
Séminaire PMMH - Avin Babataheri (Ladhyx)
1D confinement controls cell shape and migration
Pericytes are mural cells of the microvasculature, they wrap around small vessels, support the vessels mechanically and participate in blood flow regulation.
Pericytes are distinguished by two main characteristics ; first their distinct morphology, which has been likened to a “bump on a log”, as they present long processes spanning along the axis of the vessels they adhere to, and a protruding soma that houses the nucleus. The second characteristic is their distribution along the microvascular tree in a cellular chain where each cell occupies its own territory. This spatial distribution is established by cell migration during the embryonic stage and maintained through controlled motility in the adult.
Because of their position in the microvascular tree, pericytes experience extreme lateral and longitudinal confinement, we hypothesize that the confinement impacts their morphology. Although pericyte shape is key for their function during vascular regulation, the manner in which pericyte morphology is associated with migration and function remains unknown.
In this project, we use micropatterns to mimic pericyte adhesion to microvessels, we show that lateral confinement controls cell shape and produces in vivo-like phenotypes. We study pericyte migration on both laterally confining lanes, and longitudinally constraining motifs and propose a model that describes their kinetics as a stochastic motion with dry friction.
In vivo pericytes can bridge nearby capillaries, we show that in vitro pericytes are also capable of crossing gaps of different sizes. The percentage of crossings is correctly predicted by the likelihood of a fluctuating system to overcome an energy barrier. Our joint experimental and theoretical approach demonstrates the effect of in vivo-like geometrical confinement on pericyte morphology and migration.
Séminaires (3)
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Séminaire PMMH - Avin Babataheri (Ladhyx)
Vendredi 20 septembre de 11h00 à 12h00 - Salle réunion PMMH 1
1D confinement controls cell shape and migration
Pericytes are mural cells of the microvasculature, they wrap around small vessels, support the vessels mechanically and participate in blood flow regulation. Pericytes are distinguished by two main characteristics ; first their distinct morphology, which has been likened to a “bump on a log”, as they present long (...) -
Séminaire PMMH - Souhayl Sadik from (Aarhus University)
Vendredi 27 septembre de 11h00 à 12h00 - Salle réunion PMMH 1
Nonlinear Anisotropic Viscoelasticity
In this work, we revisit the mathematical foundations of nonlinear viscoelasticity. We study the un- derlying geometry of viscoelastic deformations, and in particular, the intermediate configuration. Starting from the direct multiplicative decomposition of the deformation gradient F = FeFv, into elastic and (...) -
Séminaire PMMH - Denis Dumont (IUSTI Marseille)
Vendredi 29 novembre de 11h00 à 12h00 - Salle réunion PMMH 1
Rheology of sticky grains
In many powder technology processes, coating is applied to fine particles to control their properties or functionalize them. We investigated the role of a polymer coating made of PBS on silica beads. This material has been originally designed as a model cohesive granular material, whose cohesion can be finely (...)
Instructions générales pour les conférenciers
Le public du séminaire est très hétérogène (rien qu’au PMMH nous travaillons sur des thématiques très diverses, mécanique des fluides, des milieux granulaires, des solides, physique statistique, physique du mouillage, micro-fluidique, biophysique,...) l’objectif est donc de ne pas faire un séminaire trop spécialiste : au moins la première moitié du séminaire à un niveau accessible pour celui qui ne connaît rien sur le sujet.
Le séminaire a lieu à 11h. rendez-vous 15 minutes avant pour installer et tester la projection.
Le séminaire dure environ 45 minutes pour laisser un peu de temps pour discuter à la fin.
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- Séminaire de Mécanique d’Orsay (page web FAST)
- Séminaire de Mécanique d’Orsay (page web LIMSI)
- Séminaire de Mécanique des Fluides de l’Institut Jean le Rond d’Alembert
- Séminaires du laboratoire MSC, Paris VII
- Séminaires Gulliver
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