Seminars and PhD

Seminars

PMMH’s weekly seminar is held every Friday at 11 am (map)

Contact :
Alice Pelosse
Stéphane Perrard
Etienne Reyssat
Virgile Thiévenaz
responsables-seminaires (arobase) pmmh.espci.fr

PMMH
BARRE CASSAN
BAT A 1ER ETAGE CASE 18
7 QUAI SAINT BERNARD
75005 PARIS
France

Tel : (33) 1 40 79 45 22


Séminaire PMMH — Vincent Ouazan-Reboul (LPTMS, Univ. Paris-Saclay)

Vendredi 30 octobre de 11h00 à 12h00 - Salle réunion PMMH 1

Protein assembly in and out of equilibrium

Proteins are biomolecules with intricate spatial structures, which allow them to interact through highly anisotropic, short-ranged interactions. In many cases, these interactions have been fine-tuned by evolution in order to build functional assemblies. On the other hand, many proteins self-assemble when they are not supposed to and form pathological aggregates. Strikingly, many of these aggregates are fibers, despite being made up of proteins with different spatial structures and surface chemistries.

By performing lattice Monte Carlo simulations of three-dimensional particles, I will show that anisotropic interactions lead to a great morphological diversity in the resulting assemblies. Similar to real proteins, fibers generically emerge in this model, here as a result of geometrical frustration. I will discuss how recent data hints at these fibers being long-lived metastable states. As a dual example to generic fiber assembly, I will also demonstrate that fine-tuned anisotropy is a useful design tool for controlling the size and shape of equilibrium aggregates.

Beyond equilibrium self-assembly, many proteins also possess out-of-equilibrium activity. I will discuss how, in the specific case of catalytic enzymes, activity can create chemical gradients which induce long-ranged, non-reciprocal interactions and, in turn, spatial self-organization. I will in particular show that the participation of enzymes in metabolic reaction networks qualitatively changes how they self-organize, for instance through oscillatory or network-structure-induced organization.

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Recent seminars  (5)

  • Séminaire PMMH — Constantino Tsallis (Centro Brasileiro de Pesquisas Fisicas)
    Vendredi 6 novembre de 11h00 à 12h00 - Salle réunion PMMH 1
    Nonadditive entropies : Along the Boltzmann-Gibbs legacy
    The magnificent Boltzmann-Gibbs (BG) statistical mechanics is grounded on the celebrated additive entropic functional S_BG. This theory satisfactorily describes a plethora of so-called simple systems. It fails, however, for wide classes of natural, technological and social complex systems. The violation of the (…)
  • Séminaire PMMH Annulé — Benjamin Apffel (ENS Lyon)
    Vendredi 16 octobre de 11h00 à 12h00 - Salle réunion PMMH 1
    Computing with Frustrated Space-Time Metamaterials
    Space-time metamaterials are engineered media whose constitutive parameters are modulated simultaneously in both space and time. They are now used to achieve unprecedented wave control. However, the vast majority of studies operate in the stable regime, where modulation parameters are chosen to ensure linear wave (…)
  • Séminaire PMMH — Lorène Champougny, LGC Toulouse
    Vendredi 9 octobre de 11h00 à 12h00 - Salle réunion PMMH 1
    The Fluid Mechanics of Splatter Painting
    In art, splatter painting consists in subjecting a paint-loaded brush to an acceleration (for example by “flicking” the brush or tapping its handle) to detach paint droplets or filaments. Those are projected onto the substrate to be painted, leaving filamentary or spotty patterns (Fig. 1a). In this technique, (…)
  • Séminaire PMMH — Mathis Guéneau, Max Planck Institute for the Physics of Complex Systems
    Vendredi 2 octobre de 11h00 à 12h00 - Salle réunion PMMH 1
    Spatiotemporal Characterization of Active Dynamics in Channels : Theory and Experiments
    Swimming microorganisms often live in confined, complex environments, where they transition between bulk and near-surface dynamics. Their dynamics can be quantified in terms of first-passage statistics. In this talk, I will first consider active Brownian dynamics between two walls. Using a systematic expansion, (…)
  • Séminaire PMMH - Marie Tani (Kyoto University)
    Vendredi 25 septembre de 11h00 à 12h00 - Salle réunion PMMH 1
    Swarming of Active Filaments and Collective Force Generation
    Collective motion is widely observed in nature, from schools of fish to bird flocks and insect colonies, where groups can accomplish tasks beyond the capability of individuals. Such collective behavior raises an interesting question : can a group of active agents also generate force collectively ? Here, we generate (…)
Information for the speakers

The audience is composed of people with rather heterogeneous backgrounds including specialists in solids, fluids, granular flows, statistical physics... so the idea is to keep your talk understandable by people not necessarily working in your field... The seminar time slot runs from 11am to noon so the best is to make the talk last around 45 minutes to leave some time for discussion.

PhD defense

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Auriane Huyghues-Despointes : 22/09 - 14h30
Sébastien Kuchly : 23/09 - 14h
Juliette Michaud : 28/09 - 14h
Diane Komaroff : 02/10 - 14h
Marc Vacher : 13/10
Jules Tampier : 16/10 - 13h30
Alex Le Guen : 01/12 - 14h
Elias Lundheim: 07/12 - 9h
Kexin Zhao : 17/12 - 14h30

Cofee seminar (internal, every Thursday 1h30pm) Link


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Contact

Directeur : Ramiro GODOY DIANA
Codirecteur : Laurent DUCHEMIN
Administratrice : Frédérique AUGER (01 40 79 45 22)
Gestionnaires : Claudette Barez et Edwige Declecq (01 40 79 58 53)
Courriel : dir (arobase) pmmh.espci.fr
Téléphone : 01 40 79 45 22
Adresse : PMMH UMR 7636 CNRS, ESPCI Paris-PSL, Sorbonne Université, Université Paris Cité
7 Quai Saint Bernard, Barre Cassan Bât A 1er étage Case 18, 75005 Paris